地方分会｜专科学组｜培训中心｜继续教育｜药械园地｜相关法规｜麻醉常识｜学术新知｜名医名院｜在线留言

Neurosci Lett：(-)Epigallocatechin-3-gallate decreases the s

2015-07-21 03:57 来源：编辑：麻晓点击:

2015 Jun 27;602:27-32. doi: 10.1016/j.neulet.2015.06.035. [Epub ahead of print]

(-)Epigallocatechin-3-gallate decreases the stress-induced impairment of learning and memory in rats.

Soung HS¹, Wang MH², Tseng HC³, Fang HW⁴, Chang KC⁴.

Author information

¹Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei 10608, Taiwan, PR China; Department of Psychiatry, Yuan-Shan br. of Taipei Veteran General Hospital, Yilan County 26604, Taiwan, PR China.
²Department of Anesthesia, En-Chu-Kon Hospital, Sanxia District, New Taipei City 23702, Taiwan, PR China.
³Department of Anesthesiology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei 11101, Taiwan, PR China.
⁴Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei 10608, Taiwan, PR China.

Abstract

Stress induces reactive oxygen species (ROS) and causes alterations in brain cytoarchitecture and cognition. Green tea has potent antioxidative properties especially the tea catechin (-) epigallocatechin-3-gallate (EGCG). These powerful antioxidative properties are able to protect against various oxidative damages. In this study we investigated the impact of stress on rats' locomotor activity, learning and memory. Many tea catechins, including EGCG, were examined for their possible therapeutic effects in treating stress-induced impairment. Our results indicated that locomotor activity was decreased, and the learning and memory were impaired in stressed rats (SRs). EGCG treatment was able to prevent the decreased locomotor activity as well as improve the learning and memory in SRs. EGCG treatment was also able to reduce the increased oxidative status in SRs' hippocampi. The above results suggest a therapeutic effect of EGCG in treating stress-induced impairment of learning and memory, most likely by means of its powerful antioxidative properties.

KEYWORDS:

(-) Epigallocatechin-3-gallate (EGCG); Learning and memory; Morris water maze and stress; Open field test

上一篇：Evid Based Complement Alternat Med：Use of Folk Therapy in T 下一篇：J Formos Med Assoc：Bite-force difference among obese adoles