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Mar Drugs：New Anti-Inflammatory Cembranes from the Cultured

2015-06-07 13:44 来源：编辑：麻晓点击:

2015 May 29;13(6):3443-53. doi: 10.3390/md13063443.

New Anti-Inflammatory Cembranes from the Cultured Soft Coral Nephthea columnaris.

Hsiao TH^1,², Sung CS^3,⁴, Lan YH⁵, Wang YC^6,⁷, Lu MC^8,⁹, Wen ZH¹⁰, Wu YC^11,^12,^13,¹⁴, Sung PJ^15,^16,^17,^18,¹⁹.

Author information

¹Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan. hsiaoinon@gmail.com.
²National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan. hsiaoinon@gmail.com.
³Department of Anesthesiology, Taipei Veterans General Hospital, Taipei 112, Taiwan. sung6119@gmail.com.
⁴School of Medicine, National Yang-Ming University, Taipei 112, Taiwan. sung6119@gmail.com.
⁵School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan. lanyh@mail.cmu.edu.tw.
⁶Department of Marine Biotechnology and Resources, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan. cvyc.wang@gmail.com.
⁷Division of Cardiology, Department of Internal Medicine, Kaohsiung Armed Forces General Hospital, Kaohsiung 802, Taiwan. cvyc.wang@gmail.com.
⁸Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan. jinx6609@nmmba.gov.tw.
⁹National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan. jinx6609@nmmba.gov.tw.
¹⁰Department of Marine Biotechnology and Resources, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan. wzh@mail.nsysu.edu.tw.
¹¹School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan. yachwu@mail.cmu.edu.tw.
¹²Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan. yachwu@mail.cmu.edu.tw.
¹³Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan. yachwu@mail.cmu.edu.tw.
¹⁴Center for Molecular Medicine, China Medical University Hospital, Taichung 404, Taiwan. yachwu@mail.cmu.edu.tw.
¹⁵Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan. pjsung@nmmba.gov.tw.
¹⁶National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan. pjsung@nmmba.gov.tw.
¹⁷Department of Marine Biotechnology and Resources, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan. pjsung@nmmba.gov.tw.
¹⁸Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan. pjsung@nmmba.gov.tw.
¹⁹Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan. pjsung@nmmba.gov.tw.

Abstract

Two new cembranes, columnariols A (1) and B (2), were isolated from the cultured soft coral Nephthea columnaris. The structures of cembranes 1 and 2 were elucidated by spectroscopic methods. In the anti-inflammatory effects test, cembranes 1 and 2 were found to significantly inhibit the accumulation of the pro-inflammatory iNOS and COX-2 protein of the lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells. Compound 1 exhibited moderate cytotoxicity toward LNCaP cells with an IC50 value of 9.80 μg/mL.

KEYWORDS:

COX-2; Nephthea columnaris; antiinflammatory; cembrane; cytotoxicity; iNOS; octocoral

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