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Mar Drugs:New Anti-Inflammatory Cembranes from the Cultured

2015-06-07 13:44  来源:  编辑:麻晓   点击:
2015 May 29;13(6):3443-53. doi: 10.3390/md13063443.

New Anti-Inflammatory Cembranes from the Cultured Soft Coral Nephthea columnaris.

Hsiao TH1,2, Sung CS3,4, Lan YH5, Wang YC6,7, Lu MC8,9, Wen ZH10, Wu YC11,12,13,14, Sung PJ15,16,17,18,19.

Author information

  • 1Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan. hsiaoinon@gmail.com.
  • 2National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan. hsiaoinon@gmail.com.
  • 3Department of Anesthesiology, Taipei Veterans General Hospital, Taipei 112, Taiwan. sung6119@gmail.com.
  • 4School of Medicine, National Yang-Ming University, Taipei 112, Taiwan. sung6119@gmail.com.
  • 5School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan. lanyh@mail.cmu.edu.tw.
  • 6Department of Marine Biotechnology and Resources, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan. cvyc.wang@gmail.com.
  • 7Division of Cardiology, Department of Internal Medicine, Kaohsiung Armed Forces General Hospital, Kaohsiung 802, Taiwan. cvyc.wang@gmail.com.减少缩进
  • 8Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan. jinx6609@nmmba.gov.tw.
  • 9National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan. jinx6609@nmmba.gov.tw.
  • 10Department of Marine Biotechnology and Resources, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan. wzh@mail.nsysu.edu.tw.
  • 11School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan. yachwu@mail.cmu.edu.tw.
  • 12Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan. yachwu@mail.cmu.edu.tw.
  • 13Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan. yachwu@mail.cmu.edu.tw.
  • 14Center for Molecular Medicine, China Medical University Hospital, Taichung 404, Taiwan. yachwu@mail.cmu.edu.tw.
  • 15Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan. pjsung@nmmba.gov.tw.
  • 16National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan. pjsung@nmmba.gov.tw.
  • 17Department of Marine Biotechnology and Resources, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan. pjsung@nmmba.gov.tw.
  • 18Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan. pjsung@nmmba.gov.tw.
  • 19Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan. pjsung@nmmba.gov.tw.

Abstract

Two new cembranes, columnariols A (1) and B (2), were isolated from the cultured soft coral Nephthea columnaris. The structures of cembranes 1 and 2 were elucidated by spectroscopic methods. In the anti-inflammatory effects test, cembranes 1 and 2 were found to significantly inhibit the accumulation of the pro-inflammatory iNOS and COX-2 protein of the lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells. Compound 1 exhibited moderate cytotoxicity toward LNCaP cells with an IC50 value of 9.80 μg/mL.

KEYWORDS:

COX-2; Nephthea columnaris; antiinflammatory; cembrane; cytotoxicity; iNOS; octocoral

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