中华麻醉在线
您当前位置:主页 > 热点专题 > 中国发表SCI论文汇总 >

Curr Neuropharmacol.:Targeting cytokines for morphine tolerance: a narrative review.

2018-02-24 18:25  来源:未知  编辑:高国雷   点击:

Abstract

BACKGROUND:

Despite its various side effects, morphine has been widely used in clinics for decades due to its powerful analgesic effect. Morphine tolerance is one of the major side effects which hinders its long-term usage for pain therapy. Currently, the thorough cellular and molecular mechanisms underlying morphine tolerance remain largely uncertain.

METHODS:

We searched the PubMed database with Medical subject headings (MeSH) including 'morphine tolerance', 'cytokines', 'interleukin 1', 'interleukin 1 beta', 'interleukin 6', 'tumor necrosis factor alpha', 'interleukin 10', 'chemokines'. Manual searching was carried out by reviewing the reference lists of relevant studies obtained from the primary search. The searches covered the period from inception to November 1, 2017.

RESULTS:

The expression levels of certain chemokines and pro-inflammatory cytokines were significantly increased in animal models of morphine tolerance. Cytokines and cytokine receptor antagonist showed potent effect of alliviating the development of morphine tolerance.

CONCLUSION:

Cytokines play a fundamental role in the development of morphine tolerance. Therapeutics targeting cytokines may become alternative strategies for the management of morphine tolerance.

KEYWORDS:

anti-inflammatory cytokines; chemokines; morphine tolerance; pro-inflammatory cytokines


相关推荐
网友评论
请自觉遵守互联网相关的政策法规,严禁发布色情、暴力、反动的言论。
评价:
用户名: 验证码: 点击我更换图片
 
Copyright 中华麻醉在线 All rights reserved
地址:北京市东城区东四西大街42号中华医学会南楼2单元222室麻醉学分会办公室 邮编:100710
联系人:白雪   电话:010-85158614   传真:010-85158753   京ICP备14001125
360网站安全检测平台